Planes, maintenance, and failures

[webdancer]

I was wondering if while flying the pilot keeps the engines at full throttle and doesn't adjust anything like the mixture or RPM's, does that make it
more likely that there will be a failure or will that make the cost of maintenance go up?

[nem]

I don't think it has an effect on failures or maintenance, but you will definitely pay much more for fuel - should be an incentive to adjust those
controls.

[webdancer]

With the cost of fuel. . . definitely